For my project, I wanted to know more about CRISPR and how it can benefit the health of the general population. In addition to that, I wanted to see the effects of CRISPR on the costs of medicine. For my project I followed 5 simple questions, How can CRISPR improve the health of the human
population? How much would CRISPR costs? What can people do to know more about CRISPR? What is the future of CRISPR in standard
medicine? What will hospitals do to store patient health
records regarding CRISPR?
From the research I did, I discovered a few things regarding CRISPR. The first thing I discovered was that it was first discovered by a Japanese scientist who was looking at bacteria and mainly by accident. It was something that appeared to be a mistake in the DNA of the bacteria, but when the scientist looked more into it, he found that they were spliced random DNA belonged to viruses. It lead to the discovery that the bacteria would hold DNA of a virus that previously attacked it and would use it to compare to other DNA inside itself. When the bacteria would find a match of this DNA it would cut out the virus, essentially protecting itself by holding the DNA in a storage system. Another thing I discovered was that CRISPR is a relatively new discovery regarding use for human benefit. This would appear to be kind of difficult for my research because there were limited information regarding CRISPR. A lot of articles would repeat information that I had already learned from previous articles I researched. One thing that was very surprising to me was how CRISPR has made gene editing more affordable to the scientific community. It would cut the costs of gene editing to a small percentage of what it is now. Right now, gene editing costs around a million dollars, but with CRISPR, the costs would drop to 10,000 dollars. Also the scope in which CRISPR will be used in, was very surprising to me. It can be used for humans, animals, plants, and even drugs. This technology has many possibilities and can benefit the world immensely.
The implications of this project now, are still on hold with the funding of CRISPR. As of right now the funding of CRISPR is put on hold since there are ethical concerns involved with CRISPR. For the time being CRISPR will be developed at the rate it has been over the past years. The future considerations are huge. When CRISPR gets over the hurdles regarding ethics, it will grow and be used in many fields. I would go into the possibilities but this topic is sort of beaten to death in any article regarding CRISPR. Since it is not yet developed people fantasize on the possibilities of CRISPR. But these are not unreal dreams, they are realistic (for the most part ie. designer babies) and can one day be achieved. But that one day has yet to come, and in my opinion is that the day is a far distant one indeed.
My opinion is that there needs to be more public knowledge on CRISPR, so that this can then open up the debate on the use of it in standardized medicine. Once the public is behind it, the fundings will come like a flood gate was open. The possibilities are endless, but we need to get to day one, where CRISPR is talked about in the general public.
This topic was very interesting to me and I am glad I chose it. I learned a lot about the CRISPR and will definitely be following it from now on.
From the research I did, I discovered a few things regarding CRISPR. The first thing I discovered was that it was first discovered by a Japanese scientist who was looking at bacteria and mainly by accident. It was something that appeared to be a mistake in the DNA of the bacteria, but when the scientist looked more into it, he found that they were spliced random DNA belonged to viruses. It lead to the discovery that the bacteria would hold DNA of a virus that previously attacked it and would use it to compare to other DNA inside itself. When the bacteria would find a match of this DNA it would cut out the virus, essentially protecting itself by holding the DNA in a storage system. Another thing I discovered was that CRISPR is a relatively new discovery regarding use for human benefit. This would appear to be kind of difficult for my research because there were limited information regarding CRISPR. A lot of articles would repeat information that I had already learned from previous articles I researched. One thing that was very surprising to me was how CRISPR has made gene editing more affordable to the scientific community. It would cut the costs of gene editing to a small percentage of what it is now. Right now, gene editing costs around a million dollars, but with CRISPR, the costs would drop to 10,000 dollars. Also the scope in which CRISPR will be used in, was very surprising to me. It can be used for humans, animals, plants, and even drugs. This technology has many possibilities and can benefit the world immensely.
The implications of this project now, are still on hold with the funding of CRISPR. As of right now the funding of CRISPR is put on hold since there are ethical concerns involved with CRISPR. For the time being CRISPR will be developed at the rate it has been over the past years. The future considerations are huge. When CRISPR gets over the hurdles regarding ethics, it will grow and be used in many fields. I would go into the possibilities but this topic is sort of beaten to death in any article regarding CRISPR. Since it is not yet developed people fantasize on the possibilities of CRISPR. But these are not unreal dreams, they are realistic (for the most part ie. designer babies) and can one day be achieved. But that one day has yet to come, and in my opinion is that the day is a far distant one indeed.
My opinion is that there needs to be more public knowledge on CRISPR, so that this can then open up the debate on the use of it in standardized medicine. Once the public is behind it, the fundings will come like a flood gate was open. The possibilities are endless, but we need to get to day one, where CRISPR is talked about in the general public.
This topic was very interesting to me and I am glad I chose it. I learned a lot about the CRISPR and will definitely be following it from now on.
It was quite interesting to learn that CRISPR was first discovered by Japanese scientist who stumbled upon the technology by accident. And how they were "spliced random DNA belonged to viruses". It is also interesting to learn about the ways gene editing could actually help involve healthcare, despite the ethical concerns like of the designer babies. I found a recent article on CRISPR (https://www.wired.com/story/crispr-therapeutics-plans-its-first-clinical-trial-for-genetic-disease/) that stated that a new study published in the Proceedings of the National Academy of Sciences suggested that "genetic variation between patients may affect the efficacy and safety of Crispr-based treatments enough to warrant custom treatments. " This means that CRISPR companies will just need to ensure and prove to the regulators that their treatments are safe enough to be used in humans. I can see that CPISPR is slowly becoming more of a reality than a fantasy. I would really like to learn more about how CRISPR would tackle the "designer babies" concerns, and how companies working on developing CRISPR would ensure that it is safe in the long run, and that the cost of gene editing would not rise afterwards.
ReplyDeleteWe learn so much about gene editing because it can address genetic problems. The Wired article that Alice mentioned (https://www.wired.com/story/crispr-therapeutics-plans-its-first-clinical-trial-for-genetic-disease/ has a nice video that explains how CRISPR works. The article points out that Crispr’s leading researchers formed three companies—Caribou Biosciences, Editas Medicine, and Crispr Therapeutics—to take what they had done in their labs and use it to cure human disease. For nearly five years the “big three’ Crispr biotechs have been promising precise gene therapy solutions to inherited genetic conditions. And now, one of them says it’s ready to test the idea on people. Check out the link. CRISPR is not sitting still, though researchers of gene drives are trying to figure out ways to not make cell changes permanent.
DeleteI found this topic to be the most interesting topic. Learning about CRSIPR and how gene mutation is becoming more and more real is a bit scary. We all heard about the designer babies and test tube babies how parents pick and choose who they want to have a kid with to have a perfect child. It is still proven to be impossible because we cant be sure many of the characteristics that the child may have. I think our fantasy of gene mutation and manipulation is becoming more real. What we should be careful of those who can use this to hurt people rather than help. We can use CRISPR to get rid of certain diseases but what would happen if bio-warfare becomes real? Would we be able to stop a terrorist from mutating genes that can kill more people than to help?
ReplyDeleteSeems like when you enter the realm of gene editing, many scenarios of gloom and fear enter the picture. Best to stick to the data and science on this first.
DeleteIt is surprising to know Crispr only costs 10,000 dollars?After reading the articles "Gene
ReplyDelete‘Designer Babies’? Highly Unlikely, Scientists Say"("https://www.nytimes.com/2017/08/04/science/gene-editing-embryos-designer-babies.html) I figure it is very hard to "design" a baby, and it is even impossible to do that. To modify a baby's traits, hundreds of thousands of genes will be required to change. However, I still hold my belief in modifying genes. I hope Crispr would be used in the right ways, which mean they are not used to create a small pox to kill one million people, etc.
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